Biodistribution of SPIO labeled nanomaterials

Time series of magnetically labeled cells demonstrating A: visible signal loss in the spleen at 0 Hours, 3 hours, 6 hours and 24 hours after IV injection of magnetic iron oxide labeled mouse macrophages. Labeled cell density determined from T2 maps vs. time in Spleen, Lung and Liver obtained from this whole body data set collected B: every 30 minutes and C: every other day . Acquired in collaboration with the laboratory of H. Gendelman.

Time series of magnetically labeled cells

For further information, see:

  1. Zelivyanskaya ML, Nelson JA, Poluektova L, Uberti M, Mellon M, Gendelman HE, Boska MD. Tracking superparamagnetic iron oxide labeled monocytes in brain by high-field magnetic resonance imaging. J Neurosci Res. 2003; 73(3) : 284-95.
  2. Liu Y, Uberti MG, Dou H, Banerjee R, Grotepas CB, Stone DK, Rabinow BE, Gendelman HE, Boska MD. Ingress of blood-borne macrophages across the blood-brain barrier in murine HIV-1 encephalitis. J Neuroimmunol. 2008; 200(1-2) : 41-52.
  3. Beduneau A, Ma Z, Grotepas CB, Kabanov A, Rabinow BE, Gong N, Mosley RL, Dou H, Boska MD, Gendelman HE. Facilitated monocyte-macrophage uptake and tissue distribution of superparmagnetic iron-oxide nanoparticles. PLoS ONE. 2009; 4(2) : e4343.

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