Joanne Chang

Environment, socioeconomic, sexual behavioral factors and Human Herpesvirus 8 infection in a Nationally Representative Population-based sample in Uganda

OBJECTIVES:
Human herpesvirus 8 (HHV8) is the infectious cause of Kaposi Sarcoma (KS) and is prevalent, but unevenly distributed in Africa. It is a necessary, but insufficient cause of KS. Especially a study shows that high lytic anti-HHV8 antibody titers and detection of HHV8 DNA in peripheral blood are risk factors for KS, and in people with acquired immune deficiency syndrome (AIDS).1 The Center of Disease Control (CDC) conducted a survey called the Uganda HIV/AIDS Serobehavioral survey (UHSBS) in 2004-2005. It is a cross-sectional nationally representative sample of the adult population in Uganda that has been well-characterized by questionnaire and laboratory markers for sexual risk factors, socioeconomic characteristics, common infections by antibody, including HIV, hepatitis B virus (HBV), herpes simplex 2 (HSV2), syphilis, and HHV8. To investigate the patterns of HHV8 seropositivity and the explanatory risk factors using samples from individuals aged 15-59 years randomly selected from UHSBS.

METHODS:
The study population (n=2681) was randomly selected from a population-based Uganda HIV/AIDS Serobehavioral Survey in 2004/2005. Anti-HHV8 antibodies were tested by two enzyme immunoassays based on synthetic peptides encoded by K8.1 and orf65 viral genes. Adjusted odds ratios and 95% confidence interval s were estimated using logistic regression and factor analysis to determine the pattern of HHV8 seropositivity with these explanatory factors.

Publication
Chang JT, Shebl FM, Pfeiffer RM, Biryahwaho B, Graubard BI, Mbulaiteye SM. A population-based study of Kaposi Sarcoma-associated herpesvirus seropositivity in Uganda using principal components analysis. Infect Agent Cancer. 2013 Jan 16;8(1):3. doi: 10.1186/1750-9378-8-3. 

About Joanne
Joanne was born in Taiwan. She finished my undergraduate degree in Biochemistry at the University of Washington in Seattle in 2007. After Joanne graduated, she worked at Fred Hutchinson Cancer Research Center in HIV Vaccine Trial Network in Seattle before she continued my education in public health. Joanne graduated from University of Michigan School of Public Health in April 2012 with a MPH in Epidemiology and a certificate in Public Health genetic.
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