Chu-Wei Hung

Environmental Risk Factors of Hepatocellular Carcinoma in Egypt - A Case Control Study

ABSTRACT: In Egypt, several small-scale hospital-based studies have tried to describe the association between viral risk factors and hepatocellular carcinoma (HCC). Our recent population-based study suggested that environmental factors may contribute to the incidence of HCC in Egypt. Other studies show that the Schistosomiasis infection may play an important role in liver cancer among Egyptians. Since farmers are more likely to be exposed to pesticide and living in rural areas are more likely to be infected by Schistosoma through irrigation water, the higher risk of developing HCC among farmers and rural residents is suggested. To identify the environmental and occupational risk factors in addition to viral infection in the etiology of liver cancer in Egypt, a hospital-based case-control study was conducted during December 2007 to December 2008. 150 HCC cases and 150 sex- and age- matched controls were recruited at Tanta Cancer Center and Gharbiah Cancer Society. Exposure data were collected by interviewer-administrated questionnaires. Data analysis is ongoing. Conditional logistic regression will be conducted to analyze the association between HCC and environmental exposures, adjusting for confounders. Potential pathways of the environmental risk factors in the etiology of HCC will be examined by assessing the roles of smoking behavior and Schistosomiasis.