Brooke Spencer

Inflammatory Breast Cancer in Egypt

ABSTRACT: Approximately ten percent of all breast cancer in Egypt is inflammatory breast cancer (IBC). There is significant morbidity and mortality associated with this diagnosis although incidence is quite low. In Egypt the majority of IBC diagnoses occur between the age of 30-60 years old with the greatest increase in incidence between 55-59 years old (1) Women in Egypt have a higher age specific mortality between 30-60 years old, when compared to women from the U.S. Women in Egypt are five times more likely to be diagnosed with IBC. (2) It is known that in the U.S. IBC as compared to non IBC carries a significantly worse prognosis with 32% three year survival as compared to 60% three year survival. (3) Factors that effect development of IBC in Egyptian women include older age at first child, menopausal status, shorter duration of breast feeding and increased BMI, environmental toxins. The purpose of this study was to conduct a retrospective analysis of survival trends for Egyptian women with Inflammatory Breast Cancer (IBC) as compared to non IBC treated at the National Cancer Institute during 2000-2006. Epidemiologic, pathologic and clinical data were collected on sixty five women diagnosed with IBC and fifty one women diagnosed with non IBC breast cancer. The mean age of patients was 51 (range of 28-79). Survival outcomes were estimated using SAS computerized method. Cox proportional hazards models were fit to determine differences in survival between the cases and the control groups. The median follow up was approximately 2.4 years for both groups. There were 34% (22/65) recurrences in the IBC group and (7/51)=13.7 % in the non IBC group. There were 41 deaths in the IBC group (24 were cancer related) and 12 deaths in the non IBC group (6 of which were cancer related).

1. MECC (Middle East Cancer Consortium) 1996-2001
2. Cancer Causes Control.  1999. Oct 10 (5):345-7
3. Merajver.  Genetic Determinants of Aggressive Breast Cancer. 2007; 3(46) 341-354

Survival of Inflammatory Breast Cancer Patients Compared to Non-inflammatory Breast Cancer Patients in Egypt