Differentiation

Regulation (differentiation)

The differentiation of stem cells/progenitors entails attenuation of signaling that maintain these cells in a proliferative and an uncommitted state and a contemporaneous acquisition of competence to respond to temporally and spatially arrayed epigenetic cues for differentiation. Intrinsic factors that play important role in regulating the competence of neural stem cells/progenitors belong to families of basic helix-loop-helix (bHLH) transcription factors, i.e., Neurogenin, NeuroD, Atonal and Achaete-Scute families. A link between the maintenance of neural stem cells/progenitors and competence is demonstrated by the interactions between Notch signaling and differentiation promoting neural bHLH factors. Our lab is interested in understanding how epigenetic factors, e.g., CNTF, influence cell intrinsic factors (bHLH and chromatin remodeling factors) for promoting differentiation of ocular neural progenitors along a particular sub-lineage.  

Regulation of stem cells/progenitors differentiation
Regulation of stem cells/progenitors differentiation

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Electrophysiological profile of a differentiated retinal stem cells/progenitors
Electrophysiological profile of a differentiated retinal stem cells/progenitors

 

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