Richard A. Reinhardt, D.D.S., Ph.D.

Richard A. Reinhardt, D.D.S., Ph.D.

Dr. Richard ReinhardtTitle: Professor, Co-Director Undergraduate Periodontics, BJ & Ann Moran Professor of Periodontology
Surgical Specialties Department

Room: 2170A
UNMC College of Dentistry
40th and Holdrege
Box 830740
Lincoln, NE 68583-0740

Telephone: (402) 472-1287
Fax: (402) 472-5290


  • D.D.S. University of Nebraska, Lincoln, Nebraska
  • M.S. University of Nebraska, Lincoln, Nebraska
  • Ph.D. University of Nebraska Graduate College, Omaha, Nebraska
  • Diplomate, American Board of Periodontology

Teaching Responsibilities:

  • Director PERIO 553 Periodontal Therapy
  • Co-Director PERIO 629/630 Clinical Periodontics II
  • Co-Director PERIO 696 Clinical Periodontics III
  • Director PERIO 977M Prosthodontic & Periodontal Interrelationships
  • Director PERIO 871 Advanced Periodontology

Research Interests:

  • Immunoregulation of periodontal disease and bone metabolism (cell culture and in vivo)
  • Effectiveness of periodontal maintenance therapy


  • April 2013 to April 2014 Dentotropic Pluronics as Novel Formulation Excipients for Oral Hygiene Products.  IADR/GlaxoSmithKline Innovation in Oral Care Award: Wang,, D., Reinhardt, R.A.
  • July 2012 to December 2013 Treatment of Temporomandibular Joint Idiopathic Arthritis with Simvastatin versus Corticosteroid Therapy in Rats.  Growth & Development Postgraduate Research Fund: Reinhardt, R.A., Owen, C.M.
  • July 2010 to June 2012 The Biochemical Effects of Simvastatin-Alendronate Combination on LPS-Induced Periodontitis.  Surgical Specialties Postgraduate Research Fund: Reinhardt, R.A., Le, H-O.
  • July 2010 to June 2012 The Effects of Simvastatin-Alendronate Combination in the Treatment of Experimentally-Induced Periodontitis in a Rat Model:  Bone Loss Effects.  Surgical Specialties Postgraduate Research Fund: Reinhardt, R.A., Price, U.
  • June 2011 to December 2011 Treatment of Diabetic Periodontal Disease.  American Diabetes Association: Kador, P., Reinhardt, R.A.
  • July 2010 to December 2011 Effect of Intra-articular Injection of Simvastatin on TMJ Inflammation.  Growth & Development Postgraduate Research Fund: Reinhardt, R.A., George, M.
  • July 2009 to December 2010  Effects of Prophylactic versus Therapeutic Administration of Simvastatin on Alveolar Bone Loss in Endotoxin-Induced Periodontitis Utilizing a Rat Model.  Growth & Development Postgraduate Research Fund:  Reinhardt, R.A., Powell, S.
  • July 2009 to June 2011 Pharmaco-Manipulation of Statin-Induced Bone:  Impact of Local and Systemic Alendronate.  Surgical Specialties Postgraduate Research Fund: Reinhardt, R.A., Rakes, P.

Recent Publications:

  • Price, U., Le, H.O., Powell, S.E., Schmid, M.J., Marx, D.B., Zhang, Y., Wang, D., Narayana, N., Reinhardt, R.A.  Effects of local simvastatin-alendronate conjugate in preventing periodontitis bone loss.  J Periodontal Res 2012 (Epub ahead of print).
  • Killeen, A.C., Rakes, P.A., Schmid, M.J., Zhang, Y., Narayana, N., Marx, D.B., Payne, J.B., Wang, D., Reinhardt, R.A.  Impact of local and systemic alendronate on simvastatin-induced new bone around periodontal defects.  J Periodontol 83: 1463-1471, 2012.
  • Lee, Y., Liu, X., Nawshad, A., Marx, D.B., Wang, D., Reinhardt, R.A.  Role of prostaglandin pathway and alendronate-based carriers to enhance statin-induced bone.  Mol Pharm 8:1015-1042, 2011.
  • Payne, J.B., Stoner, J.A., Lee, H.M., Nummikoski, P.V., Reinhardt, R.A., Golub, L.M.  Serum bone biomarkers and oral/systemic bone loss in humans.  J Dent Res 90:747-751, 2011.
  • Payne, J.B., Golub, L.M., Stoner, J.A., Lee, H.M., Reinhardt, R.A., Sorsa, T., Slepian, M.J.  The effect of subantimicrobial-dose doxycycline periodontal therapy on serum biomarkers of systemic inflammation: a randomized, double-masked, placebo-controlled clinical trial.  J Am Dent Assoc 142:262-273, 2011.
  • Kador, P., O'Meara, J.D., Blessing, K., Marx, D.B., Reinhardt, R.A.  Efficacy of structurally-diverse aldose reductase inhibitors on experimental periodontitis in rats.  J Periodontol 82:926-933, 2011.
  • Rutledge, J., Schieber, M.D., Chamberlain, J.M., Byarlay, M., Killeen, A.C., Giannini, P.J., Marx, D.B., Reinhardt, R.A.  Simvastatin application to augment facial jaw bone in a dog model:  pilot study.  J Periodontol 82:597-605, 2011.
  • Kador, P.F., Hamada, T., Reinhardt, R.A., Blessing, K.  Effect of an aldose reductase inhibitor on alveolar bone loss associated with periodontitis in diabetic rats.  Postgrad Med 122:138-144, 2010.
  • Chen, R., Rice, K.C., Liu, X.M., Reinhardt, R.A., Bayles, K.W., Wang, D.  Triclosan-loaded tooth-binding micelles for prevention and treatment of dental biofilm.  Pharm Res 27:2356-2364, 2010.. 
  • Golub, L.M., Lee, H.M., Stoner, J.A., Reinhardt, R.A., Sorsa, T., Gioren, A.D., Payne, J.B.  Doxycycline effects on serum bone biomarkers in post-menopausal women.  J Dent Res 89:644-649, 2010.
  • Reinhardt, R.A., Stoner, J.A., Golub, L.M., Lee, H.M., Nummikoski, P.V., Sorsa, T., Payne, J.B.  Association of gingival crevicular fluid biomarkers during periodontal maintenance with subsequent progressive periodontitis.  J Periodontol 81:251-259, 2010.
  • Chen, F., Liu, X.M., Rice, K.C., Li, X., Yu, F., Reinhardt, R.A., Bayles, K.W., Wang, D.  Tooth-binding micelles for dental caries prevention.  Antimicrob Agents Chemother 53:4898-4902, 2009..
  • Mikuls, T.R., Payne, J.B., Reinhardt, R.A., Thiele, G.M., Maziarz, E., Cannella, A.C., Holers, V.M., Kuhn, K.A., O'Dell, J.R. Antibody responses to Porphyromonas gingivalis (P. gingivalis)in subjects with rheumatoid arthritis and periodontitis. Int Immunopharmacol 9:38-42, 2009.
  • Golub, L.M., Lee, H.M., Stoner, J.A., Sorsa, T., Reinhardt, R.A., Wolff, M.S., Ryan, M.E., Nummikoski, P.V., Payne, J.B. Subantimicrobial-dose doxycycline modulates gingival crevicular fluid biomarkers of periodontitis in postmenopausal osteopenic women. J Periodontol 79:1409-1418,2008.
  • Al-Salleeh, F., Beatty, M.W., Reinhardt, R.A., Petro, T.M., Crouch, L. Human osteogenic protein-1 induces osteogenic differentiation of adipose-derived stem cells harvested from mice. Archs Oral Biol 53:928-936,2008.
  • Morris, M., Lee, Y., Lavin, M.T., Giannini, P.J., Schmid, M.J., Marx, D.B., Reinhardt, R.A. Injectable simvastatin in periodontal defects and alveolar ridges: pilot studies. J Periodontol 79:1465-1473,2008.
  • Liu, X.M., Wiswall, A.T., Rutledge, J.E., Akhter, M.P., Cullen, D.M., Reinhardt, R.A., Wang, D. Osteotropic beta-cyclodextrin for local bone regeneration. Biomaterials 29:1686-92, 2008.
  • Lee, Y., Schmid, M.J., Marx, D.B., Beatty, M.W., Cullen, D.M., Collins, M.E., Reinhardt, R.A. The effect of local simvastatin delivery strategies on mandibular bone formation In vivo. Biomaterials 29:1940-9, 2008.

Service Activities:

  • Consultant, Veterans Administration Medical Center, Lincoln, NE
  • Senior Dental Consultant, Ameritas Group, Lincoln, NE
  • CRDTS Examiner