Jeffrey B. Payne, D.D.S., M.Dent.Sc.

Jeffrey B. Payne, D.D.S., M.Dent.Sc.

Dr. Jeffrey PayneTitle: Professor and Associate Dean for Research,
F. Gene and Rosemary Dixon Endowed Chair in Dentistry

Department of Surgical Specialties 
Cruzan Center for Dental Research
Bioregulation Group
University Dental Associates

Address
Room: 2051.DA
UNMC College of Dentistry
40th and Holdrege
Box 830740
Lincoln, NE 68583-0740

Telephone: (402) 472-1318
Fax: (402) 472-6668
email

Education:

  • Diplomate, American Board of Periodontology
  • Certificate (Periodontology), University of Connecticut School of Dental Medicine, Farmington, Connecticut
  • M.Dent.Sc. (Immunology), University of Connecticut School of Dental Medicine, Farmington, Connecticut
  • D.D.S., State University of New York at Stony Brook School of Dental Medicine, Stony Brook, New York
  • B.S. (Biology), Adelphi University, Garden City, New York

Teaching Responsibilities:

  • Perio 538 Theoretical Periodontology
  • Perio 331 Theoretical Periodontology
  • OB 471 A Review of Biomedical/Dental Sciences

Research Interests:

  • Periodontitis and systemic diseases (including osteoporosis and rheumatoid arthritis)
  • Clinical periodontal pharmacologic interventions
  • Periodontitis clinical trials

Grants:

  • July 1, 2010 to June 30, 2014 (includes one-year, no-cost extension) Periodontal Disease and P. gingivalis in Rheumatoid Arthritis, American College of Rheumatology, Co-Investigator
  • July 1, 2010 to June 30, 2013 (includes one-year, no-cost extension) Examining Multilevel Associations in Dental Research, National Institute of Dental and Craniofacial Research, Co-Investigator (Principal Investigator on Subcontract)
  • July 1, 2006 to December 31, 2008 Low-dose Doxycycline Effects on Osteopenic Bone Loss, National Institute of Dental and Craniofacial Research, Principal Investigator
  • July 1, 2001-June 30, 2006 Low-dose Doxycycline Effects on Osteopenic Bone Loss, National Institute of Dental and Craniofacial Research, Principal Investigator
  • July 1, 2001-June 30, 2006 Low-dose Doxycycline Effects on Osteopenic Bone Loss, National Institute of Dental and Craniofacial Research, Supplement, Principal Investigator

Completed Book Chapter:

  • Stoner, J.A., Payne, J.B. Subantimicrobial-dose doxycycline effects on alveolar bone loss in postmenopausal women. Example of a randomized controlled clinical trial. In Statistical and methodological aspects of oral health research, eds. Lesaffre, E., Feine, J., Leroux, B., Declerck, D., pp. 359-376. John Wiley & Sons, Ltd., 2009.

Recent Publications:

  • Mikuls, T.R.,  Payne, J.B., Yu, F., Thiele, G.M., Reynolds, R.J., Cannon, G.W., Markt, J., McGowan, D., Kerr, G.S., Redman, R.S., Reimold, A., Griffith, G., Beatty, M., Gonzalez, S., Bergman, D.A., Hamilton, B.C., Erickson, A.R., Sokolove, J., Robinson, W., Walker, C., Chandad, F., O'Dell, J.R.  Periodontitis and Porphyromonas givgivalis in patients with rheumatoid arthritis.  Arthritis Rheum 66: 1090-1100, 2014. 
  • Payne, J.B., Nummikoski, P.V., Thompson, D.M., Golub, L.M., Stoner, J.A. The association between clinical and radiographic periodontitis measurements during periodontal maintenance. Journal of Periodontology 84: 1382-1390, 2013.
  • Salminen, A., Pirkko, J. P., Payne, J. B., Stoner, J. A., Jauhiainen, M., Golub, L. M., Lee, H. M., Thompson, D. M., Sorsa T.  Subantimicrobial dose doxycycline treatment increases serum cholesterol efflux capacity from macrophages.  Inflamm Res 62:711-720, 2013.
  • Mikuls, T.R., Thiele, G.M., Deane, K.D., Payne, J.B., O'Dell, J.R., Yu, F., Sayles, H., Weisman, M.H., Gregersen, P.K., Buckner, J.H., Keating, R.M., Derber, L.A., Robinson, W.H., Holers, V.M., Norris, J.M.  Porphyromonas gingivalis and disease related autoantibodies in individuals at increased risk for future rheumatoid arthritis. Arthritis Rheum 64: 3522-3530, 2012.
  • Gu, Y., Walker, C., Ryan, M.E., Payne, J.B., Golub, L.M.  Non-antibacterial tetracycline formulations: clinical applications in dentistry and medicine. J Oral Microbiology 2012;4.doi:10.3402/jom.v4i0.19227.
  • Payne, J.B., Golub, L.M., Stoner, J.A.  Response to Bretz review J Evid Base Dent Pract 2011 (letter to the editor);11:194-195. J Evid Base Dent Pract 12:178-179, 2012.
  • Killeen, A.C., Rakes, P.A., Schmid, M., Zhang, Y., Narayana, N., Marx, D.B., Payne, J.B., Wang, D., Reinhardt, R.A.  Impact of local and systemic alendronate on simvastatin-induced new bone around periodontal defects. Journal of Periodontology 83:1463-1471, 2012.
  • Mikuls, T.R., Thiele, G.M., Payne, J.B.  Periodontitis and Porphyromonas gingivalis:  Possible roles in rheumatoid arthritis risk and progression. Int J Clin Rev 2012;04:01.doi:10.5275/ijcr:2012.04.01.
  • Payne, J.B., Golub, L.M., Stoner, J.A., Lee, H.M., Reinhardt, R.A., Sorsa, T., Slepian, M.J. The effect of subantimicrobial-dose-doxycycline treatment of periodontitis on serum biomarkers of systemic inflammation: a randomized, double-masked placebo-controlled clinical trial. J Am Dent Assoc 142: 262-273, 2011.
  • Payne, J.B., Stoner, J.A., Lee, H.M., Nummikoski, P.V., Reinhardt, R.A., Golub, L.M. Serum bone biomarkers and oral/systemic bone loss in humans. J Dent Res 90:747-751, 2011.
  • Gonzalez, SM, Spalding, P.M., Payne, J.B., Giannini, P.J. A dentigerous cyst associated with bilaterally-impacted mandibular canines: a case report. J Med Case Reports 5:230, 2011.
  • Payne, J.B., Golub, L.M. Using tetracyclines to treat osteoporotic/osteopenic bone loss: From the basic science laboratory to the clinic. Pharmacol Res 63:121-129, 2011.
  • Golub, L.M., Lee, H.-M., Stoner, J.A., Reinhardt, R.A., Sorsa, T. Goren, A.D., Payne, J.B. Doxycyline effects on serum bone biomarkers in post-menopausal women. J Dent Res 89:644-649, 2010.
  • Reinhardt, R.A., Stoner, J.A., Golub, L.M., Lee, H.M., Nummikoski, P.V., Sorsa, T., Payne, J.B. Association of gingival crevicular fluid biomarkers during periodontal maintenance with subsequent progressive periodontitis. Journal of Periodontology 81:251-259, 2010.
  • Mikuls, T.R., Payne, J.B., Reinhardt, R.A., Thiele, G.M., Maziarz, E., Cannella, A.C., Holers, V.M., Kuhn, K.A., O'Dell, J.R. Antibody responses to Porphyromonas gingivalis (P. givgivalis) in subjects with rheumatoid arthritis and periodontitis. Int Immunopharmacol 9:38-42, 2009.
  • Golub, L.M., Lee, H.M., Stoner, J.A., Sorsa, T., Reinhardt, R.A., Wolff, M.S., Ryan M.E., Nummikoski, P.V., Payne, J.B. Subantimicrobial dose doxycycline modulates gingival crevicular fluid biomarkers of periodontitis in postmenopausal osteopenic women. Journal of Periodontology 79:1409-1418, 2008.
  • Stoner, J.A., Payne, J.B. Interpretation of treatment effects in periodontal research. A note on the number needed to treat. Journal of the Canadian Dental Association 74:435-437, 2008.
  • Payne, J.B., Stoner J.A., Nummikoski, P.V., Reinhardt, R.A., Goren, A.D., Wolff, M.S., Lee, H.M., Lynch, J.C., Valente, R., Golub, L.M. Subantimicrobial dose doxycycline effects on alveolar bone loss in postmenopausal women. Journal of Clinical Periodontology 34:776-787, 2007.
  • Preston, R.D., Meinberg, T.A., Payne, J.B., Schmid, M.J., Lee, H.M., Golub, L.M., Marx, D.B., Reinhardt, R.A. Inflammatory mediator release following bone grafting in humans: a pilot study. Journal of Clinical Periodontology 34:797-804, 2007.
  • Reinhardt, R.A., Stoner, J.A., Golub, L.M., Wolff, M.S., Lee, H.M., Meinberg, T.A., Lynch, J.C., Ryan, M.E., Sorsa, T., Payne, J.B. Efficacy of subantimicrobial dose doxycycline in postmenopausal women: clinical outcomes. Journal of Clinical Periodontology 34:768-775, 2007.
  • Walker, C., Puumala, S., Golub, L.M. Stoner, J.A., Reinhardt, R.A., Lee, H.M., Payne, J.B. Subantimicrobial dose doxycycline effects on osteopenic bone loss: microbiology results. Journal of Periodontology 78:1590-1601, 2007.
  • Golub , L.M., Payne, J.B., Reinhardt, R.A., Neiman, G. Can Systemic Diseases Co-Induce (NOT just Exacerbate) Periodontitis? A Hypothetical "Two-Hit" Model. J Dent Res. 85:102-105, 2006.
  • Reinhardt, R.A., Lee, H.M., Schmid, M., Payne, J.B., Golub, L. Relationship between gelatinases and bone turnover in the healing bone defect. J Oral Maxillofac Surg 85:102-105, 2006.

Recent Abstracts:

  • Sellers, R.M., Payne, J.B., Yu, F., LeVan, T.D., Walker, C., Mikuls, T.R.  TLR-4 polymorphism: protective against alveolar bone loss and Porphyromonas gingivalis-associated periodontitis?  J Dent Res 93 (Spec. Is.):Abstract 639, 2014. 
  • Redman, R.S., Kerr, G.S., Nylén, E.S., Mikuls, T.R., Payne, J.B., Huang, J.S., Kokkinos, J.P., Becker, K.L.  Salivary and serum procalcitonin and C-reactive-protein as potential periodontitis biomarkers.  J Dent Res 93 (Spec.Is.):Abstract 605, 2014.
  • Mikuls, T.R., Payne, J., Yu, F., Thiele, G.M., Gonzalez, S., Markt, J., Sokolove, J., Reimond, A.M., Griffiths, G., Beatty, M., Schmid, M., Johnson, P., Bergman, D., Hamilton, B., Erickson, A.R., O'Dell, J.R.  Alveolar bone loss is associated with disease activity and ACPA expression in rheumatoid arthritis.  Arthritis Rheum 65 (suppl): s345, 2013.
  • Mikuls, T.R., Payne, J., Yu, F., Thiele, G.M., Reynolds, R.J., Cannon, G.W., Markt, J., McGowan, D., Kerr, G.S., Redman, R., Reimold, A.M., Griffiths, G., Beatty, M., Gonzalez, S., Bergman, D., Hamilton, B., Erickson, A.R., O'Dell, J.R.  Associations of periodontitis (PD) with established seropositive rheumatoid arthritis are independent of smoking and other risk factors.  Arthritis Rheum 65 (suppl): s582, 2013.
  • Mikuls, T.R., Payne, J., Sayles, H., Gonzalez, S., Markt, J., Beatty, M., Cannon, G.W., McGowan, D., Kerr, G.S., Redman, R., Reimold, A.M., Griffiths, G. Poor to moderate performance of patient self-report in identifying periodontitis in patients with rheumatoid arthritis.  Arthritis Rheum 64 (suppl): s89, 2012.
  • Thompson, D.M., Stoner, J.A., Payne, J.B. Interpreting parameter estimates that distinguish multilevel effects in oral health research. Joint Statistical Meetings: Poster Session 253, 2012
  • Stoner, J.A., Thompson, D.M., Payne, J.B.  Distinguishing multilevel effects in oral health research. Joint Statistical Meetings: Poster Session 659, 2012.
  • Payne, J.B., Nummikoski, P.V., Thompson, D.M., Golub, L.M., Stoner, J.A. Association between longitudinal changes in clinical and radiographic periodontitis measures. J Dent Res 91 (Spec. Is.):Abstract 749, 2012.
  • Thompson, D.M., Lee, H., Stoner, J., Golub, L.M., Nummikoski, P.V., Payne J. Association between serum inflammatory biomarkers and progression of periodontics. J Dent Res 91 (Spec. Is.):Abstract 750, 2012.
  • Mikuls, T.R., Deane, K.D., Payne J., Thiele, G.M., O'Dell, J.R., Derber, L.A., Robinson, W.H., Holers, V.M., Norris J.M.  Porphyromonas Gingivalis (P. gingivalis) is associated with the presence of disease-specific autoantibodies in individuals at increased risk for the future development of rheumatoid arthritis. Arthritis Rheum 63 Suppl 10:766, 2011.
  • Stoner, J.A., Nummikoski, P., Golub L., Thompson, D.M., Payne, J.B. Association between longitudinal changes in alveolar bone height and density. J Dent Res 90 (Spec. Is.):Abstract 3092, 2011.
  • Payne, J.B., Stoner, J.A., Lee, H.M., Nummikoski P.V., Reinhardt, R.A., Golub, L.M. Association between serum-bone formation/bone-turnover biomarkers and alveolar and systemic bone loss. J Dent Res 89 (Spec. Is.):Abstract 1267, 2010.
  • Payne, J.B., Stoner, J.A., Lee, H.M., Golub, L.M. Subantimicrobial-dose doxycycline effects on serum inflammatory biomarkers in postmenopausal-osteopenic-women with periodontitis. J Dent Res 88 (Spec. Is.):Abstract:2916, 2009.
  • Golub, L.M., Lee, H.M., Stoner, J.A., Payne, J.B. Serum gelatinases Type IV collagenases in postmenopausal-osteopenic women with periodontitis: subantimicrobial-dose-doxycycline (SDD). J Dent Res 88 (Spec. Is.):Abstract 3512, 2009.
  • Reinhardt, R.A., Stoner, J.A., Golub, L.M., Lee, H.M., Payne J.B. GCF MMP-8 in postmenopausal women. Association with progressive attachment loss. J Dent Res 88 (Spec. Is):Abstract 2917, 2009.
  • Mikuls, T.R., Payne, J.B., Reinhardt, R.A., Thiele, G.M., Maziarz, E., Cannella, A.C., Holers, V.M. Kuhn, K.A., Bergman, D.A., O'Dell, J.R. Immunity to the oral pathogen, Porphyromonas gingivalis (P. givgivalis) in subjects with rheumatoid arthritis and periodontitis. Arthritis Rheum 58(suppl), s274, 2008.
  • Reinhardt, R.A., Stoner, J.A., Golub, L.M., Lee, H.-M., Payne, J.B. Longitudinal GCF biomarkers associated with ongoing clinical attachment loss. Journal of Periodontology 79:1818-1819, 2008.
  • Payne, J.B., Stoner, J.A., Lee, H.M., Nummikoski, P.V., Reinhardt, R.A., Valente, R., Golub, L.M. Serum bone-resorption biomarkers: correlation with alveolar and systemic bone changes. J Dent Res 87 (Spec. Is.): Abstract 1558, 2008.
  • Golub, L.M., Lee, H.M., Stoner, J.A., Reinhardt, R.A., Sorsa, T., Goren, A.D., Payne, J.B. Bone-turnover markers in postmenopausal osteopenic women with periodontitis (POWP): Subantimicrobial-dose doxycycline (SDD). J Dent Res 87 (Spec. Is.): Abstract 3491, 2008.
  • Reinhardt, R.A., Stoner, J.A., Lee, H.M., Nummikoski, P.V., Golub, L.M., Payne, J.B. Crevicular fluid resorption marker: correlations with alveolar and systemic bone changes. J Dent Res 87 (Spec. Is.): Abstract 2909, 2008.
  • Reinhardt, R.A., Stoner, J.A., Golub, L.M., Wolff, M.S., Lee, H.M., Lynch, J.C., Nummikoski, P.V., Goren, A.D., Sorsa, T., Payne, J.B. Subantimicrobial-dose doxycycline in postmenopausal osteopenic women with periodontitis: clinical outcomes. J Dent Res 86 (Spec. Is.): Abstract 1331, 2007.
  • Payne, J.B., Nummikoski, P.V., Stoner, J.A., Reinhardt, R.A., Goren, A.D., Wolff, M.S., Lee, H.M., Lynch, J.C., Gruber, B., Golub, L.M. Subantimicrobial-dose doxycycline in postmenopausal osteopenic women with periodontitis: radiographic outcomes. J Dent Res 86 (Spec. Is.): Abstract 1332, 2007.
  • Walker, C., Puumala, S.E., Golub, L.M., Stoner, J.A., Reinhardt, R.A., Lee, H.M., Payne, J.B. Low-dose doxycycline effects on osteopenic bone loss: microbiology results. J Dent Res 86 (Spec. Is.): Abstract 1333, 2007.
  • Golub, L.M., Lee, H.M., Stoner, J.A., Sorsa, T., Reinhardt, R.A., Wolff, M.S., Ryan, M.E., Payne, J.B. Subantimicrobial-dose doxycycline (SDD) in postmenopausal osteopenic women with periodontitis: GCF biomarkers. J Dent Res 86 (Spec. Is.) Abstract 1334, 2007.
  • Payne, J.B., Stoner, J.A., Reinhardt, R.A., Wolff, M.S., Lynch, J.C., Layton, J.A., Lee, H-M, Lahners, A., Meinberg, T., Goren, A.D., Ryan, M.E., Golub, L.M. Doxycycline effects on osteopenic bone loss: trial design and recruitment. J Dent Res 84 (Spec. Is.): Abstract 1537, 2005

Service Activities:

  • Chair, College of Dentistry Research Committee
  • Chair, Cruzan Center for Dental Research Board of Directors
  • Member Audit Committee, Omicron Kappa Upsilon, Supreme Chapter
  • Member, University of Nebraska Medical Center Research Resources Board
  • Member, University of Nebraska Medical Center Translational Research and Biotechnology Council
  • Member, University of Nebraska Medical Center Clinical Research Advisory Board
  • Member, College of Dentistry Leadership Council
  • Member, College of Dentistry Administrative Review Committee
  • Member, College of Dentistry Strategic Planning Committee
  • Member, College of Dentistry Accreditation Steering Committee
  • Consultant, Veterans Administration Medical Center, Lincoln NE

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